(2-Methyl-4-(piperidin-1-ylsulfonyl)-phenyl)boronic acid
(2-Methyl-4-(piperidin-1-ylsulfonyl)-phenyl)boronic acid
CAS: 1217501-52-4
Molecular Formula: C12H18BNO4S
(2-Methyl-4-(piperidin-1-ylsulfonyl)-phenyl)boronic acid - Names and Identifiers
(2-Methyl-4-(piperidin-1-ylsulfonyl)-phenyl)boronic acid - Physico-chemical Properties
| Molecular Formula | C12H18BNO4S |
| Molar Mass | 283.15 |
| Density | 1.33±0.1 g/cm3(Predicted) |
| Boling Point | 488.5±55.0 °C(Predicted) |
| pKa | 8.13±0.58(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | IRRITANT |
| MDL | MFCD13195672 |
(2-Methyl-4-(piperidin-1-ylsulfonyl)-phenyl)boronic acid - Introduction
(2-Methyl-4-(piperidin-1-ylsulfonyl)-phenyl)boronic acid, also known as (2-Methyl-4-(piperidin-1-ylsulfonyl)-phenyl)boronic acid, is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: White to light yellow crystal
-Molecular formula: C14H19BN2O4S
-Molecular weight: 318.28g/mol
-melting point: 147-152 ℃
-Solubility: Soluble in some organic solvents, such as dimethyl sulfoxide (DMSO), dichloromethane and ethanol, but insoluble in water.
Use:
(2-Methyl-4-(piperidin-1-ylsulfonyl)-phenyl)boronic acid is commonly used as a reagent in organic synthesis and has the following uses:
-Catalyst: It can be used as a palladium-catalyzed hydrogenation reagent for reduction and cross-coupling reactions in organic synthesis reactions.
-Pharmaceutical research: Due to its boron and sulfonyl groups, this compound can be used to design and synthesize some pharmaceutical molecules.
Preparation Method:
Generally,(2-Methyl-4-(piperidin-1-ylsulfonyl)-phenyl)boronic acid can be synthesized through the following steps:
1. 2-methylphenylboronic acid (2-methylphenylboronic acid) reacts with piperidine sulfonyl chloride (piperidine-sulfonyl chloride) under alkaline conditions.
2. The target compound is generated accordingly.
Safety Information:
There is limited safety information about (2-Methyl-4-(piperidin-1-ylsulfonyl)-phenyl)boronic acid. Users should pay attention to the following when using this compound:
-This compound may be irritating to the eyes, skin and respiratory system, so appropriate personal protective measures are required.
-During operation, avoid inhalation or contact with skin. At the same time, it must be ensured that the operation is carried out in a well-ventilated laboratory.
-Please follow the correct operating methods and laboratory safety regulations when using, and follow the relevant safety data sheet.
This information is for reference only. Please read the relevant literature and safety data sheets carefully before use, and take necessary protective measures according to the specific situation.
Nature:
-Appearance: White to light yellow crystal
-Molecular formula: C14H19BN2O4S
-Molecular weight: 318.28g/mol
-melting point: 147-152 ℃
-Solubility: Soluble in some organic solvents, such as dimethyl sulfoxide (DMSO), dichloromethane and ethanol, but insoluble in water.
Use:
(2-Methyl-4-(piperidin-1-ylsulfonyl)-phenyl)boronic acid is commonly used as a reagent in organic synthesis and has the following uses:
-Catalyst: It can be used as a palladium-catalyzed hydrogenation reagent for reduction and cross-coupling reactions in organic synthesis reactions.
-Pharmaceutical research: Due to its boron and sulfonyl groups, this compound can be used to design and synthesize some pharmaceutical molecules.
Preparation Method:
Generally,(2-Methyl-4-(piperidin-1-ylsulfonyl)-phenyl)boronic acid can be synthesized through the following steps:
1. 2-methylphenylboronic acid (2-methylphenylboronic acid) reacts with piperidine sulfonyl chloride (piperidine-sulfonyl chloride) under alkaline conditions.
2. The target compound is generated accordingly.
Safety Information:
There is limited safety information about (2-Methyl-4-(piperidin-1-ylsulfonyl)-phenyl)boronic acid. Users should pay attention to the following when using this compound:
-This compound may be irritating to the eyes, skin and respiratory system, so appropriate personal protective measures are required.
-During operation, avoid inhalation or contact with skin. At the same time, it must be ensured that the operation is carried out in a well-ventilated laboratory.
-Please follow the correct operating methods and laboratory safety regulations when using, and follow the relevant safety data sheet.
This information is for reference only. Please read the relevant literature and safety data sheets carefully before use, and take necessary protective measures according to the specific situation.
Last Update：2024-04-09 21:54:55
